Berberina Optimum Berbevis® extract 550 mg, 30 capsules

Boost your metabolism with Berberine Optimum with Berbevis® extract! Natural control of blood sugar, cholesterol and triglycerides

Berberina Optimum with Berbevis® extract 550 mg is a natural dietary supplement that helps maintain normal blood glucose, triglyceride and cholesterol levels and is recommended for maintaining metabolic health.

Berberine Optimum 550 mg contains standardized Berberis aristata Berbevis® Berberine standardized extract, an innovative Phytosome® technology, which combines raw Berberis aristata extract, sunflower phospholipids, pea protein and grape seed extract, significantly improving berberine absorption.

Thanks to the Phytosome® technology developed by Indena, this combination provides 8-10 times higher absorption than standard berberine. This increased bioavailability allows metabolic efficiency even at a low dose, only 550 mg/day. Berbevis® extract is ideal for long-term consumption. In addition, the capsules are easier to administer due to their small size, making the product suitable for people who have difficulty swallowing the capsules.

In contrast to Berberis vulgaris extract, the Berberis aristata extract used in Berberina Optimum with Berbevis® extract is easier to tolerate and is the best choice for people who have experienced gastric discomfort when consuming berberine, but also for long-term use.

How helps Berberina Optimum with Berbevis® extract 550 mg from Zenyth?

• Supports cardiovascular health.
• Maintains normal blood glucose levels.
• Lowers plasma triglyceride levels.
• Normalizes cholesterol levels.
• Helps reduce body weight.
• Promotes gastrointestinal health.
• antioxidant effect.
• Strengthens immunity.
• Supports digestive system (antifungal and intestinal antimicrobial).
• Improves insulin sensitivity.
• Regulates lipid metabolism.
• Promotes glucose absorption at cellular level.
• Helps reduce oxidative stress and inflammation.
• Supports growth of good gut bacteria.
  

What is berberine?

Berberine is a naturally occurring compound extracted from plants, known for its intense yellow color and bitter taste, but especially for its impressive health benefits. Used for centuries in traditional Chinese and Ayurvedic medicine, berberine is recognized for its antidiabetic, cardioprotective, antioxidant, antimicrobial, antibacterial, anti-infectious, antidiarrheal and antifungal, neuroprotective, anti-obesity and hepatoprotective properties.

Berberine, a natural alternative to conventional anti-diabetics?

Berberine is gaining increasing attention as a natural alternative to conventional anti-diabetic drugs. Recent studies have shown that berberine has a hypoglycemic action comparable to that of metformin, a commonly prescribed drug for type 2 diabetes.

A 2008 study showed that taking 500 mg of berberine two or three times a day for three months can help keep blood glucose levels within normal limits and optimize lipid metabolism (J. Yin et all, 2008)³.

While standard forms of berberine require doses of up to 1500 mg per day, the patented Berbevis® extract can provide similar effects with as little as 550 mg per day.

Berberine may help lower blood glucose levels through several mechanisms:

• AMPK enzyme activation. Berberine influences the enzyme AMPK, which plays a crucial role in maintaining cellular energy homeostasis and controlling fat and carbohydrate metabolism.
• Improves insulin sensitivity by, stimulating glucose uptake and utilization in the body, which helps lower blood glucose.
• Modulation of insulin receptors. Berberine acts on insulin receptors, helping to decrease insulin resistance in cells, thus facilitating the glucose utilization process.
• Influencing gluconeogenesis, a process by which the liver synthesizes glucose, thereby helping to maintain a balanced blood sugar level.
• Slow carbohydrate breakdown. Berberine can reduce the rate of carbohydrate absorption in the gut, thereby preventing rapid spikes in blood glucose after meals.

Berbevis® berberine extract, a patented innovation with clinically proven efficacy!

Berbevis® is an innovative form of berberine, the result of advanced phytomedicine research and Indena’s patented Phytosome® technology. Obtained from the roots of the Berberis aristata plant, recognized for centuries in traditional Ayurvedic medicine, this berberine is standardized to contain 28-34% berberine in free form (analyzed by HPLC). What sets Berbevis® apart from conventional forms is its complex structure, optimized for superior absorption and improved tolerability.

Berberine with super absorption: the Phytosome® innovation behind Berbevis®

Berbevis® uses an innovative technology called Phytosome®, which helps the body absorb berberine much more easily. Instead of using just plain berberine, this formula combines it with phospholipids (extracted from sunflower) and pea proteins, forming a stable complex that is easily recognized and taken up by the body. This natural ‘packaging’ makes berberine up to 10 times better absorbed than the classic form, which can otherwise pass largely through the gut without being used effectively.

In other words, what does this mean for you? Instead of taking large and frequent doses of regular berberine, with Berbevis® you need a smaller amount, but with similar or even stronger effects because your body manages to use it better. And that means less risk of digestive discomfort.

Higher potency in a lower dose. Berbevis® combines effectiveness with digestive comfort!

Thanks to improved absorption, Berbevis® offers comparable, or even superior, metabolic effects to traditional forms of berberine, with a daily dose of just 550 mg. In addition, its advanced formula includes grape seed extract, with its antioxidant and protective role on the intestinal mucosa, significantly reducing the risk of gastric discomfort, which is common with conventional berberine in people with digestive sensitivity.

Studies confirm that Berbevis® extract brings visible results in metabolic health

Berbevis® is one of the few forms of berberine supported by multiple controlled clinical trials.

For example, in a randomized study conducted on women with polycystic ovary syndrome (PCOS), “Berbevis® supplementation (550 mg twice/day for 90 days) resulted in resumption of regular menstruation in 70% of cases and reduction in acne and hirsutism, without significant adverse effects” (F. Pierro et al., 2023)¹.

A study in overweight people with altered basal blood glucose showed that “Berbevis®, taken at a dose of 550 mg twice a day for 60 days, can significantly lower blood glucose and insulin levels” (M. Rondanelli et al., 2023)². In addition, significant improvements in the blood lipid profile (cholesterol and triglycerides) and a reduction in abdominal fat and waist circumference were observed.

A number of additional studies also indicate that a single daily dose of 550 mg of Berbevis® can help maintain a balanced lipid profile and support healthy body composition, even in the absence of a restrictive diet, in both individuals with stable and occasional hyperlipidaemia. In addition, significant improvements in HOMA, an important marker of insulin resistance, were observed after only 30 days of administration, suggesting a potential role in optimizing the metabolism of insulin resistance.

Safe choice for long-term use: Berbevis® and its safety profile

Unlike other forms of berberine that can pose liver or digestive problems, the patented Berbevis® extract offers an improved safety profile and is suitable for long-term use. This formula supports metabolic and hormonal health through scientifically validated mechanisms and is an ideal choice for individuals who want an effective and well-tolerated solution for the body.

Why choose Berberine Optimum with Berbevis® extract 550 mg? Here are 4 reasons!

1. Increased digestive tolerance: standardized extract of Berberis aristata Berbevis®, a form of berberine gentle on the stomach, which limits the occurrence of digestive discomfort or nausea. So people with digestive sensitivities can use berberine safely and comfortably, confident that it will provide the desired benefits without the discomfort associated with other supplements.
2. Superior ingredient quality: patented Berbevis® extract, a standardized ingredient from Berberis aristata, with 28-34% free-form berberine, optimized by Phytosome® technology for superior absorption and high metabolic efficiency, even at low doses.
3. Guaranteed purity: product contains no lactose, gluten, magnesium stearate or artificial sweeteners.
4. Clean label: transparent label details all ingredients and their standardization.

Berberine versus raised cholesterol and triglycerides. Who wins?

Recent research has shown that berberine can effectively lower cholesterol and triglyceride levels, thereby contributing to cardiovascular health.

Here’s how the mechanism works.

• Activation of the AMPK enzyme improves glucose and lipid utilization, helping the body to burn fat more efficiently and lower cholesterol levels.
• Regulates LDL receptors. Berberine stimulates the expression of LDL (low-density lipoprotein) receptors in the liver. These receptors are responsible for the absorption of cholesterol from the blood. An increase in the number of LDL receptors means that the liver will remove more cholesterol from the circulation, thus helping to lower total and LDL cholesterol levels.
• Reducing intestinal absorption of cholesterol. Berberine helps decrease the absorption of cholesterol from the intestines by increasing its excretion in feces. This reduces the amount of cholesterol reaching the bloodstream.
• The decrease in triglyceride synthesis is achieved with the help of berberine, by inhibiting the activity of enzymes that contribute to triglyceride formation, thus helping to lower triglyceride levels in the blood, an important risk factor for cardiovascular disease.
• Effect on apolipoprotein B. Recent studies suggest that berberine may reduce levels of apolipoprotein B, a major component of LDL. By inhibiting the synthesis of this protein, berberine helps to reduce the formation of harmful lipoproteins and thus the risks associated with heart disease.

In addition to reducing cholesterol and triglycerides, berberine also helps improve the overall lipid profile. For example, a meta-analysis study concluded that taking berberine significantly lowered triglycerides, total and LDL cholesterol and increased HDL (high-density lipoprotein) levels, also known as ‘good cholesterol’.

Berberine supports healthy weight loss

One of the main mechanisms by which berberine contributes to weight loss is by improving insulin sensitivity. It facilitates efficient utilization of glucose by cells, reducing fat deposition and stimulating fat burning. Activation of the enzyme AMPK is crucial in this process, contributing to more efficient energy metabolism.

Berberine also reduces fat absorption in the gut, which means fewer calories are available for storage. Berberine’s prebiotic effect supports the growth of beneficial bacteria in the gut, which contributes to better digestion and optimal metabolism.

Berberine Optimum with Berbevis® extract 550 mg is a food supplement.

Food supplements do not replace a varied and balanced diet and a healthy lifestyle! Do not exceed the recommended daily intake! Keep out of the reach and sight of small children!

Manufacturer/Notification Holder: Zenyth Pharmaceuticals SRL, loc. Alexandru cel Bun, jud. Neamț, Romania. Notification to SNPMAPS, no. 18032/2025.

Sources

¹ https://pubmed.ncbi.nlm.nih.gov/38074133/

² https://www.europeanreview.org/article/33142

³ https://pubmed.ncbi.nlm.nih.gov/18442638/